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SARS-CoV-2 ORF3a Peptide (KIITLKKRWQLALSK)
Coronavirus Peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Sequence | KIITLKKRWQLALSK |
|---|---|
| Purity | >90% (HPLC-MS) |
Application 
| Cellular immune response, T-cell expansion, Antigen specific T-cell stimulation, Immune monitoring, T-cell assays |
| Primary Accession | P0DTC3 |
| Gene ID | 43740569 |
|---|---|
| Other Names | ORF3a protein, Accessory protein 3a, Protein 3a, Protein U274, Protein X1 |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | 3a |
|---|---|
| Function | ORF3a forms homotetrameric potassium sensitive ion channels (viroporin) and may modulate virus release. Up-regulates expression of fibrinogen subunits FGA, FGB and FGG in host lung epithelial cells. Induces apoptosis in cell culture. Downregulates the type 1 interferon receptor by inducing serine phosphorylation within the IFN alpha-receptor subunit 1 (IFNAR1) degradation motif and increasing IFNAR1 ubiquitination. |
| Cellular Location | Virion membrane, host endoplasmic reticulum-Golgi intermediate compartment membrane |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
SARS-CoV-2 infection induces a storm of cytokines in later stages of progression. The viral protein ORF3a activates the NLRP3 inflammasome via promotion of TNF receptor-associated factor 3 (TRAF3)-mediated ubiquitination of apoptosis-associated speck-like protein containing a caspase recruitment domain (ASC). ORF3a protein activates pro-IL-1β gene transcription and protein maturation, two signal essential to activation of the NLRP3 inflammasome.
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